Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF OLANZAPINE

Md. Shabuddin*, T. Praveen Kumar, Ch. Sowjanya, Dr. P. Suresh Kumar, Syed Yasmin Sulthana and Dr. V. Jagannath Patro

Abstract

The objective of this study was to prepare the orally dissolving films of Olanzapine which can be used as Anti emetic, Antipsychotic Agent, Serotonin Uptake Inhibitors. The orally disintegrating films (ODF) of Olanzapine were prepared by solvent casting method using different water soluble low viscosity grades of polymers such as HPMC E3, HPMC E6 and HPMC E15. The films were characterized for various physicochemical properties such as thickness measurement, weight variation, % drug content, folding endurance, In vitro disintegration time, In vitro dissolution time. The experimental results indicated that polymer concentration; plasticizer concentration had complex effects on % drug release. In this study best formulation was chosen from each polymer based on release parameters. It was found that with HPMC E3, F1 was found to be best formulations, with HPMC E6, F5 and F6 was found to be best formulation and with HPMC E15, F9 were found to be best formulations. The prepared film was clear, transparent and had a smooth surface. The DSC and FTIR study revealed no drug polymer interactions. The prepared orally dissolving films have good commercial success after performing the stability study.

Keywords: Olanzapine, orally disintegrating films, Serotonin Uptake Inhibitor, solvent casting.