Abstract

FORMULATION AND EVALUATION OF REPAGLINIDE TRANSDERMAL PATCHES FOR TREATMENT OF DIABETES

Gauri A. Nilewar*, Prashant L. Takdhat, Shruti M. Thakre and Parag D. Bhagwatkar

Abstract

The objective of present study was to develop Repaglinide transdermal patches for treatment of diabetesusing Hydroxypropyl methyl cellulose(HPMC), ethyl cellulose in different ratios. Tri-ethyl citratewas used as a plasticizer and methylene chlorideused as a permeation enhancers which were added by solvent casting method. Results revealed that prepared patches showed good physical characteristics, no drug-polymer interaction and no skin irritation was observed. The systems were evaluated for various parameters like weight uniformity, folding endurance, thickness, drugcontent. The systems were evaluated for various in vitro, Ex vivo, in vivo(skin irritation, anti-diabetic activity in rats) parameters. In- vitro diffusion studies and Exvivo studies were performed by using Franz diffusion cells. The in vitro release study revealed that Cformulation showed maximum release in 24hrs. From all the formulations, formulation C was selected as best formulation and was stable for 60% RH.

Keywords: Repaglinide, Hydroxypropylmethylcellulose, Ethylcellulose, Transdermal patches.