Abstract

DISCUSSION ABOUT NARIAL DRUG DELIVERY

*Sneha Sharma

Abstract

Interest in intranasal (IN) or intranarial administration as a noninvasive route for drug delivery continues to grow rapidly. The nasal mucosa offers numerous benefits as a target issue for drug delivery, such as a large surface area for delivery, rapid drug onset, potential for central nervous system delivery, and no first-pass metabolism. A wide variety of therapeutic compounds can be delivered IN, including relatively large molecules such as peptides and proteins, particularly in the presence of permeation enhancers. The current review provides indepth discussion of anatomy and physiology of nose, advantages and limitations of nasal route, various factors affecting nasal formulations and barrier to nasal cavity, and various nasal formulations. It is anticipated that the present review will prove useful for considering IN delivery as a delivery route.

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