Abstract

EPITOMIZATION OF BIPHASIC MINI-TABLETS BY USING NATURAL POLYMERS FOR COLON SPECIFIC CHRONOTHERAPEUTIC DRUG DELIVERY

Sandeep Pasunooti*, Rahul Shukla and Venkanna Pasham

Abstract

Solid oral tablet dosage forms are one of the most admissible dosages by majority of individuals. In these days increased focus on development of multiple units of single dose effectively compressed into biphasic drug delivery instead of filling into capsules. Propranolol hydrochloride is a medication of the non-selective beta blocker it is suitable drug to formulate as compression coated colon specific biphasic mini-tablets at predetermined release rates, in this fast release mini-tablets gives fast onset of action, delayed release mini-tablets to maintain plasma concentration. Fast, delayed release mini-tablets are prepared direct compression process and coating material prepared by wet granulation method to protect core from upper GI tract by taking different proportions of (F1 to F13) microbial degraded natural (Guar gum, xanthan gum, chitosan) and pH dependent polymers. The results of dissolution studies of formulation containing F13 was shows burst and delayed drug release up to 24hr at targeted region, phosphate buffer containing 4% w/v rat caecal substance and control have clarified the sensitivity of the natural polymers to the colonic enzymatic organism action with subsequent drug release. It follows all the kinetic mechanisms; FT-IR information showed that there is no conceivable between drug and excipients.

Keywords: Propranolol hydrochloride, Compression coated colon specific biphasic minitablets, HPMC K 15 M, Guar gum, Xanthan gum, Chitosan.