Abstract

FORMULATION AND EVALUATON OF FLOATING TABLET OF ACYCLOVIR

Deepika*, Rizwana Khan, Dr. Bhawna Sharma

Abstract

Floating drug delivery Systems has received considerable interest in the past few decades as they were overcome the drawbacks of conventional drug delivery system like frequent dosing, low bioavailability etc. relative to fast gastric-emptying time. wet granulation method was used for preparation of floating tablets. An optimum floating drug delivery System was defined as a system that remains in the stomach for sufficient interval of time and releases the active medicament in a sustained manner. These remain floating on the gastric contents. Thus resulting in prolonged pharmacological effect the improving the bioavailability of drug. The aim of writing this research was to prepare optimized floating tablets of Acyclovir which were evaluated for various parameters like Weight Variation, Hardness, Friability, Angle of Repose, Flow Rate, Bulk density, Tapped Density, Carr‟s Index, Thickness, Diameter, floating lag time, duration of floating time, Invitro drug release studies, data treatment, in- vivo and Stability Studies of floating tablets.

Keywords: Floating tablets, bioavailability, Gastro retentive, prolonged release.