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Abstract

IN VITRO AND IN VIVO STUDIES OF THE IMMUNOMODULATORY EFFECT OF CINNAMOMUM MALABATRUM ON FEMALE WISTAR RATS

Simi George* and Veena R.

Abstract

Background: For thousands of years, cinnamon has been known as one of the most common spices, with multiple culinary usages. They have become very familiar immunomodulatory herbal medicine. However, the specific immunomodulatory effect of this particular species remains to be elucidated. Objective: The objectives of the study was to evaluate the immunomodulatory effect of ethanolic extract of Cinnamomum malabatrum in cell mediated immunity and to analyze its invito efficacy. Methods: The assessment of cell mediated immunity was carried out by neutrophil adhesion test order to induce immunostimulation, Levamisole (50mg/kg/day, p.o.) was used. The invitro effects of the extract was measured by cell proliferation method in followed by MTT assay using murine macrophage cell line stimulated by lipopolysaccharide (LPS). Results: Ethanolic extract of Cinnamomum malabatrum evoked a significant increase in percentage neutrophil adhesion to nylon fibers Both doses of the extract produced significant results in neutrophil adhesion tests when compared to control. Also in invitro tests, the extract produced dose dependent increase in cell proliferation effect in LPS stimulated macrophage cell line.(264.7 cell l ine). Conclusion: From the results of invivo test and invitro test, using the ethanolic extract, it can be concluded that ethanolic extract of Cinnamomum malabatrum has a significant immunomodulatory effect on experimental animals and cell lines which may be attributed to the terpenoid and flavonoid content of the plant extract.

Keywords: Cinnamomum malabatrum, immunomodulatory, Levamisole, Neutrophil adhesion, Cell proliferation, MTT.


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