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Abstract

FORMULATION AND EVALUATION OF NITROFURANTOIN BILAYER TABLET

Kirti D. Tirkhunde* and Atul A. Phatak

Abstract

Nitrofurantoin (NFT) is an antibacterial drug. Nitrofurantoin is slightly soluble in water. Nitrofurantoin shows both bacteriostatic and bactericidal effects. Bacteriostatic or bactericidal effect inhibits the synthesis of DNA, RNA, protein and cell wall synthesis. The sustained release tablet will optimize safety of a drug and therapeutic effect. Main aim to prepare sustained release tablet is patient convenience and compliance. The study deals with Nitrofurantoin (NFT) bi-layer tablet. This helps in reducing frequent dosing and to overcome patient compliance. The bi-layer tablet contains immediate release and sustained release layer. To prolong the effect of dug release by adding control releasing agent i.e, Carbopol71G.The optimized batch shows the 98% release in 8 hrs. In batch T5 the release was very fast as required to maintain the release up to 8 hrs. X-ray diffraction (XRD), Differential scanning calorimetry (DSC), Fourier Transform Infrared (FTIR) spectra study was carried out.

Keywords: Nitrofunrantoin, Bilayer tablet, Dry mix, X-ray diffraction, Differential scanning calorimetry, Fourier Transform infrared (FTIR).


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