Abstract

DEVELOPMENT AND IN VITRO- IN VIVO EVALUATION OF GASTRO RETENTIVE DRUG DELIVERY OF NIZATIDINE USING NATURAL AND SEMI- SYNTHETIC POLYMERS

S. Shyamla*, K. Selvaraju, K. S. G. Arulkumaran, R. Gayathri and R. Pradeepa

Abstract

Nizatidine is a competitive reversible inhibitor of histamine H2 receptors, particularly in the gastric parietal cells. Floating modified release nizatidine tablets were prepared using the direct compression method. Tablets were formulated using natural polymers tamarind seed polysaccharide, semi-synthetic polymer Hydroxypropyl methyl cellulose (HPMC K4M). The pre formulation and post formulation parameters such as Angle of repose, Bulk density, tapped density thickness, hardness, friability and drug content were evaluated. In vivo study was performed by using the rabbits by X-ray imagining technique, radiological evidences suggest that a formulated tablet was well floated more than 10h in rabbit‟s stomach. Statistical data analysis revealed that tablets containing a composition of tamarind polysaccharide 15% w/w and HPMC K 15%w/w produced the most favourable formulation to develop 12 hours controlled release tablets with optimum floating behaviour and satisfactory physicochemical characteristics. Furthermore, F8 in vitro release study revealed that the formulated floating tablet had significantly lower buoyancy lag time and higher total floating time compared to the other formulations. Comparative kinetic model obtained for the tablet of F8 depends on r2 in zero order kinetics and mechanism was fit to Korsmeyer –Peppa‟s model. It can be concluded that the combination of tamarind seed polysaccharide and HPMC in the ratio of 1:1 it can be used to develop controlled release floating tablets of nizatidine.

Keywords: Tamarind seed polysaccharide, Floating drug delivery, Nizatidine, HPMC and Controlled release.