Abstract

MUCOADHESIVE LIPOSOME AS A PROMISING DRUG DELIVERY SYSTEM"

Priyanka Raj G.*, S. Parthiban and G. P. Senthilkumar

Abstract

Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. A liposome is a tiny bubble (vesicle), made out of the same material as a cell membrane. Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. It has been derived on the basis of name of sub cellular particles, ribosomes. Liposomes were first made by A.D Bangham in early 1960s.Their size ranges from 25 to 500nm. Gastro retentive dosage forms are having high potential for the usage as controlled drug delivery systems. A controlled release system designed to improve its residence time in stomach by making contact with the mucosa is achieved through formulating mucoadhesive liposomes.

Keywords: Liposomes, oral mucoadhesive drug delivery system.