Abstract

A REVIEW ON ESTIMATION OF EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM

Jyoti J. Vikhe*, N. S. Dighe, Prof. G. S. Shinde, Rutuja B. Tambe and Shubhangi P. Pulate

Abstract

The aim of this review to focus on comprehensive update of different analytical methods for determination of oral anti-diabetic drugs like Empagliflozin and Metformin hydrochloride for the treatment of type 2 diabetes mellitus (T2DM), such as biguanides and sodium /glucose co –transportaer 2 inhibitors in their bulk materials and in pharmaceutical dosage forms. The review entails about analytical procedures like RPHPLC, HPLC, UPLC, LC/MS/MS, Spectrophotometric (UV) methods taken from the literature. This review provides detailed information of development and validation for Empagliflozin and Metformin hydrochloride in bulk and in pharmaceutical preparations either alone or in combination with other hypoglycemic agent.

Keywords: Metformin HCL, Empagliflozin, analytical methods, antidiabetic.