Abstract

PROTECTIVE EFFECTS OF SOLANUM LYCOPERSICUM FRUIT EXTRACT ON LEAD INDUCED MICRONUCLEI IN BONE MARROW CELLS OF MICE

*K Rudrama Devi and K Dilip Reddy

Abstract

In the present investigation the antimutagenic effect of Solanumlucopercicum fruit extract has been evaluated against lead nitrateinduced genotoxicity. Single IP administration of Solanumlycopercicum fruit extract at various doses i.e. 250, 500 and 1000 mg/kg. When treated individually did not induce micronuclei inpolychromatic erythrocytes of mice. A single I P of 40mg/kg, of leadnitrate induced significant increase in the percentage of micronuclei inbone marrow cells of mice. However after co administration of threedoses of Solanum lycopercicum fruit extract there was a dosedependent decrease in the % of micronuclei was observed. Thus theresults clearly indicate the preventive effects of Solanum lycopercicum fruit extract againstlead induced genotoxicity in bone marrow cells of mice. Therefore the data indicate that SLfruit extract is a safer dietary component in cancer chemo preventive strategy.

Keywords: Solanum Lycopercicum fruit extract (SLFE), Lead Nitrate, Micronuclei.