Abstract

ANALYTICAL STANDARDIZATION OF KANYALOHADI VATI

Dr. R. M. Sireesha*, Venkata Subbaiah K. and Sridurga Ch.

Abstract

Rasa shastra is a branch of medicine which deals with preparation of drugs of metals and minerals having wide range of therapeutic efficacy and possessing innate qualities like quick action, less dose, tastelessness, prolonged shelf life and better palatability. Kanyalohadi Vati is one such Rasaoushadhi mentioned in Rasa Tantra Sara va Siddha Prayoga Sangraha indicated in Kashtartava, which contains Kaseesa bhasma as one of the ingredient along with the herbal drugs like Twak, Ela, Sunthi, Elua (Musambaram) and Gulkand. Shodhana, Marana, Elua nirmana, Gulkand nirmana and Churna Nirmana are the main pharmaceutical procedures involved in the preparation of Kanyalohadi Vati. To assure the safety and to understand about the identity, form, particle size and surface morphology of the above formulation, it was subjected to analysis through various techniques like X-ray diffraction (XRD), Scanning electron microscopy (SEM), Particle size analysis (PSA), Zeta Potential (ZP), UV-Spectroscopy, Fourier transform Infra- Red spectroscopy (FTIR) and Inductively Coupled Plasma – Optical Emission Spectrometry (ICP-OES). XRD of Kanylohadi Vati showed major peaks of Iron oxide (FeO) compound with Rhombohedral structure and Magnesium Iron Aluminium Oxide (MgFeAlO4) with cubic structure. SEM micrographs showed presence of particles which are clusters of irregular shaped flakes at 500 X, 1.00 KX, 2.00 KX & 4.00 KX magnification. Particle size was found to be 10.7 nm with Zeta Potential of -10.4 mV. UV- Spectrum of Kanylohadi Vati showed maximum absorption at 230 nm and 283 nm. FTIR test showed 17 peaks between the wavelength 3856.34 cm-1 to 404.29 cm-1. ICP–OES analysis revealed Iron and Potassium as the main constituent in 44122.23 ppm and 19640.55 ppm.

Keywords: Kanyalohadi vati, Analytical studies, Safety.