WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

REVISITING CARDIOPROTECTIVE ROLE OF CURCUMINOIDS: A COMPARISON OF CARDIAC OUTPUT, POSITIVE INOTROPIC, AND NEGATIVE CHRONOTROPIC EFFECTS IN ISOLATED PERFUSED FROG HEART PREPARATION

Vasudeva Rao Avupati*, Nalini Govindasamy, Yuawa Rani, M. Mohamed Shabi, Ashwinder Singh and Prasad Cheepurupalli

Abstract

Curcuminoids, a curcumin (C), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) were isolated from Curcuma longa L. (C. longa L) by column chromatography and evaluated for relative cardioprotective potential in isolated frog heart preparation. Although DMC and BDMC are also principal curcuminoids but most of the studies reported on the cardioprotective role of C. longa L include C as effective and bioactive curcuminoid, thus DMC and BDMC were less explored. Based on our study, the results suggest that curcuminoids (C, DMC and BDMC) could exhibit cardioprotective activity as evidenced by improved hemodynamic variables such as cardiac output, positive inotropic and negative chronotropic effects. Our results demonstrated that the C has more significant effect on cardiac output, DMC exhibited enhanced negative chronotropic effect (increased heart rate), and BDMC displayed intensified positive ionotropic effect (force of contraction) respectively, which were independently cardioprotective and revealed comparable potency with each other.

Keywords: Curcumin, demethoxycurcumin, bisdemethoxycurcumin, positive inotropic, negative chronotropic, cardiac output, cardioprotection.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More