Abstract

SOLID LIPID NANOPARTICLE: A NOVEL APPROACH IN DRUG DELIVERY SYSTEM

Debraj De*, Priyanka Ghosh and Rabindranath Pal

Abstract

Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research as well as in other varied sciences. Solid lipid nanoparticle (SLN) dispersions have been proposed as a new type of colloidal drug carrier system suitable for intravenous administration. The system consists of spherical solid lipid particles in the nanometer ranges, which are dispersed in water or in aqueous surfactant solution. It is identical to an oil-in-water emulsion for parenteral nutrition but the liquid lipid (oil) of the emulsion has been replaced by a solid lipid, i.e., yielding Solid Lipid Nanoparticles. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. Appropriate analytical techniques for characterization of solid lipid nanoparticles like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of solid lipid nanoparticles route of administration and their biodistribution are also incorporated. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases.

Keywords: Solid lipid nanoparticles (SLN), colloidal drug carriers, homogenization, TEM, PCS, biodistribution, targeting.