Abstract

FACILE GREEN SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NOVEL THIAZOLIDINONES WITH PYRIMIDINE MOIETY

Pravina Baburao Piste* and Maruti Sidhu Kanase 

Abstract

As a part of systematic investigation of synthesis and antimicrobial activity of 6-methyl-4-(Sub.)Phenyl-2-Oxo/Thioxo-1,2,3,4- Tetrahydropyrimidine-5-(2-Sub.Phenyl, 3-Amido )thiazolidine-4-ones ( IVa-l ) was achieved from corresponding Mannich Base (IIIa-l) by reaction with mercapto acetic acid and anhydrous zinc chloride for 2-3 minutes in Microwave irradiation. The synthesized compounds have been screened in vitro for their antimicrobial activity against S. aureus and E.coli. Some of the compounds displayed pronounced biological activity. The resulting products were characterized by IR, 1H NMR and Mass spectroscopic method.

Keywords: MW irradiation, Thiazolidine, Pyrimidine, Mannich bases, Antibacterial activity