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Abstract

FACILE SYNTHESIS AND ANTIMICROBIAL SCREENING OF PYRAZOLE DERIVATIVES

Pravina B. Piste*

Abstract

A series of novel and significant compounds containing pyrazole derivatives have been synthesized from base catalyzed reaction between N-acetyl-3-4-diphenylpyrazole and substituted benzaldehydes by grinding technique afforded 1-benzoaceto-3-5- diphenyldihydropyrazole (Ia-d) followed by reflux with different reagents like phenyl hydrazine ,Hydrazine hydrate in acetic acid and Hydrazine hydrate in sodium acetate gave corresponding N1-(3,4- diphenyl,5’-dihydro-2,3-pyrazol)-3,5-diphenyl,4- diydro pyrazole( IIad), N1-(4-phenyl,3-acetyl,5-dihydro,2,3-pyrazol)3,5-diphenyl-4- dihydropyrazole (IIIa-d), N1-(4-phenyl,5-dihydro-2,3-pyrazol)-3,5- diphenyl -4-dihydro pyrazole (IVa-d ) respectively. The structures of the newly synthesized compounds have been confirmed on the basis of elemental analysis and spectral data. Some of the synthesized compounds exhibit significant antibacterial activity

Keywords: Pyrazole, Grinding, Antibacterial activity


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