Abstract

PREPARATION AND CHARACTERIZATION OF CURCUMIN GOLD NANO SUSPENSION FOR BREAST CANCER

Pankti P. Dalwadi*, Dr. Pragnesh Patani and Dr. Indrajeet Singhavi

Abstract

Breast cancer is world third leading cause of death in the world among women. Breast cancer is spreads from milk duct. Nano suspension improves bioavailability of poorly soluble drugs improves therapeutic effectiveness of drug to target at the site of effectiveness. Curcumin gold nano suspension (CGNS) is prepared by Bottom –Up technology. Curcumin is obtained from rhizomes of curcuma longa. Curcumin modulate anti cancer activity by activation of NF- κB pathway.Gold has surface plasmon resonance property which reduces the dose of the chemotherapy and radiation therapy. Curcumin gold nano suspension solid particles were obtained by lyophilisation. Particle size of optimized batch of CGNS is 322.6±4.98nm and poly dispersity index of 0.18±0.020. Zeta potential of CGNS is -27.42 ±0.32. Differential scanning calorimetry shows that nano particle was in amorphous in nature. Improves dissolution rate of CGNS because of reduces particle size. Transmission Micrograph of the CGNS was show particle size of 322.6nm. The results suggested that precipitation was an effective way to prepare CGNS improves the dissolution rate for targeting cancer cells.

Keywords: Curcumin, Gold nano particle, Precipitation method, Nano suspension, Dissolution.