Abstract

EVALUATION OF WOUND HEALING EFFECT OF MAERUA OBLONGIFOLIA IN ALBINO RATS

N. Arulanand Raj*, Dr. V. Gopal, S. Dhivya and Dr. G. Jayabalan

Abstract

Background: This particular study emphasis on the in-vivo wound healing effect of Maerua oblongifolia in albino rats. Methods: Plant powder (10g) was soaked in 30 ml of ethanol (70%) in a soxhlet extractor for 72h. The extract was concentrated in a rotary flash evaporator at a temperature not exceeding 50°C. It was then evaporated to dryness. The excision wound model was employed for wound healing activity in albino rats. Healthy albino rats (150-200g) of either sex were taken for excision wound model. Animals were divided into three groups of six animals in each. The Group1 is control. The Group 2 animals were treated with Soframycin, that served as standard. Group3 animals were treated with herbal extract of Maerua oblongifolia. All animals had free access to pelleted food and water. Temperature was maintained at 23±1°C. The results were expressed as mean±SEM. Results: Complete wound healing was observed with Maerua oblongifolia treated rats in 15 days as that of Soframycin ointment. Conclusion: The findings from this research indicates that the ethanol extract of Maerua oblongifolia are effective in inhibiting the growth of wound associated pathogen and faster the process of wound healing.

Keywords: Maerua oblongifolia, Soframycin, wound model, Wound healing.