Abstract

COMPARSION STUDIES ON TRANSDERMAL FILMS OF NATURAL TAMARIND SEED POLYSACCHARIDE EXTRACT CONTAINING ANTI HYPERTENSION DRUG WITH PVA ,HPMC AND GUAR GUM.

M.SantoshNaidu, G.V.Radha, P.Girish1and D.Lohithasu*

Abstract

Objective of the study: The present study was to compare the transdermal film property of the natural Tamarind seed polysaccharide extract with the synthetic and natural polymers like PVA, HPMC and Guar gum. The transdermal films prepared by solvent casting method using Tamarind seed polysaccharide (TSP) alone and combinations with other polymers and film properties are evaluated. The release property of various film forming agent in increasing order are TSP>PVA>guar gum>HPMC. Conclusion: Tamarind seed polysaccharide (TSP) combination has showed the drug retardant property. The order of drug release for different formulation is given as follows F2>F1>F8>F7>F14>F11>F6>F5>F4>F3>F13>F12>F9>F10. Formulated Transdermal Films evaluated for various physicochemical parameters and in vitro permeation studies. Transdermal drug delivery system (TDDS) facilitates delivery of therapeutically effective amount of drug across a patient’s skin with controlled rate.

Keywords: Tamarind seed polysaccharide (TSP), Retardant property, PVA, HPMC and Guar gum.