Abstract

EVALUATION OF PHYTOCHEMICAL INVESTIGATION AND ANTICONVULSANT ACTIVITY OF AQUEOUS STEM EXTRACT OF ECLIPTA ALBA

Mahanthesh M.C*, Swati MP, Popat SK, Vikram HP, Jadhav SY, J.I.Disouza

Abstract

The present study expose that the anticonvulsant activity of Eclipta Alba (Asteraceae) stem extracts. The anti-convulsant activity of plant extracts was evaluated by using the Maximal Electroshock (MES) induced convulsion technique. The convulsions in experimental animals were induced with Maximal electroshock of 150 mA current for 0.2 sec. Then administration of normal saline, standard drug and stem extracts at respective doses. The stem extract exhibited a significant reduction in various phases of epileptic seizure. The aqueous extracts treated groups showed significant decrease in duration of flexion; clonus and stupor phase of MES induced convulsions. The Eclipta alba possessed significant anticonvulsant activity against MES and PTZ induced convulsions.

Keywords: MES, Phenytoin, Diazepam, Eclipta alba, Asteraceae.