EVALUATION OF PHYTOCHEMICAL INVESTIGATION AND ANTICONVULSANT ACTIVITY OF AQUEOUS STEM EXTRACT OF ECLIPTA ALBA
Mahanthesh M.C*, Swati MP, Popat SK, Vikram HP, Jadhav SY, J.I.Disouza
Abstract
The present study expose that the anticonvulsant activity of Eclipta
Alba (Asteraceae) stem extracts. The anti-convulsant activity of plant
extracts was evaluated by using the Maximal Electroshock (MES)
induced convulsion technique. The convulsions in experimental
animals were induced with Maximal electroshock of 150 mA current
for 0.2 sec. Then administration of normal saline, standard drug and
stem extracts at respective doses. The stem extract exhibited a
significant reduction in various phases of epileptic seizure. The
aqueous extracts treated groups showed significant decrease in
duration of flexion; clonus and stupor phase of MES induced
convulsions. The Eclipta alba possessed significant anticonvulsant activity against MES and
PTZ induced convulsions.
Keywords: MES, Phenytoin, Diazepam, Eclipta alba, Asteraceae.
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