Abstract

SIMPLE, FAST AND RELIABLE REVERSED PHASE HPLC METHOD FOR LORNOXICAM ANALYSIS IN PHARMACEUTICAL FORMULATIONS

Ehab I. Taha, Saleh A. Al-Suwayeh and Gamal M. Mahrous*

Abstract

Analysis of active ingredients is very important process during drug development and formulation. In this work a simple, fast, economic and reliable analysis method of lornoxicam was developed and validated regarding linearity, specificity, sensitivity, precision and accuracy. limit of detection and limit of quantification were found to be The method was proven to be 0.122 and 0.061 μg/ml. the method consumed very little amount of mobile phase (about 4 ml per each sample). Also the developed analytical method of LOR was very fast which was indicated by a very small retention time (about 3.6 minutes). The analytical method was tested for detection of lornoxicam in commercial Xefo® 8 mg tablets and it was proven to be very effective.

Keywords: Lornoxicam, RP-HPLC, Analysis.