Abstract

ANTIDIABETIC ACTIVITY OF CISSUS ROUTNDIFOLIA LEAVES SUPPLEMENT

Wael Mustafa Ali Mohammed*, Abdulaziz A. Y. Abbas, Hatem Mohmmed

Abstract

Botanical supplement Cissus rotundifolia (CR) belongs to Vitaceae, and has been used traditionally in Yemen. Distribute widely in Yemen regions. (CR) has been proposed to contain bioactive components having anti-diabetic properties such as flavonoid, hydrolysable tannin, antioxidants and vitamin C. They contain an appreciable amount of protein, fat, crude fiber and minerals. protein fraction contains a relatively high level of essential amino acids; fat contains a high concentration of unsaturated fatty acids; Macroelements (Magnesium, Sodium, Potassium; Microelements (Iron, Zinc, Manganese, Copper and Chromium. This study was designed to assess the efficacy and safety of (100 g & 50 g CR/patient) feeding with fresh boiled leaves for eighteen patients compared with glibenclamide drug. Hypoglycemic effects of (CR) were also investigated in diabetic patients. (CR) and the standard drug glibenclamide were orally administered daily to diabetic patients for 10 days. Blood glucose, enzymes transaminase (ALT & AST) and kidney functions levels were determined. The results have shown hypoglycemic activity in diabetic patients. Conclusion: The antihyperglycaemic activity of (CR) may probably due to the presence of several phytochemicals belonging to properties antidiabetic effect.

Keywords: Cissus rotundifolia, botanical supplement, hypoglycemic, diabetic patients.