Abstract

EVALUATION OF ANTIBIOTIC RESISTANCE CASES IN ACUTE RESPIRATORY INFECTION DISEASE: POTENTIAL TEST AND COMPARATIVE TEST OF TETRACYCLINE ANTIBIOTIC

Danni Ramdhani*, Sri Agung F. K. and Ika Khumairoh

Abstract

Objective: Acute respiratory infection (ARIs) is an acute respiratory infection that attacks the throat, nose and lungs caused by viruses, bacteria, rickettes. Antibiotics is one way to overcome the disease ARIs. Ineffective use of antibiotics may lead to resistance. The potential value of antibiotics determines the effectiveness of an antibiotic. This study aims to determine the potential value and comparative test of tetracycline antibiotics as a quality evaluation. Methods: Test the antibiotic potency with diffusion method to use 3 doses with using antibiotic samples. Comparative test of antibiotic testing by comparing samples with standard against Staphylococcus aureus ATCC 29213 test bacteria. Results: The potential value obtained was 101.7%, and comparative test was 1 : 1,08. Conclusion: The results of testing the potential of this antibiotic in accordance with the requirements contained in Indonesia Pharmacopeia. The comparative test results show that antibiotic samples used had good bacterial killing ability.

Keywords: Tetracycline, antibiotic resistence, potential test, comparative test, agar diffusion.