Abstract

FORMULATION AND EVALUATION OF LIPOSOMES CONTAINING FAMOTIDINE

Biresh K Sarkar*, Maddi Ramaiah, Manish Devgan, Y.Ankamma chowdary

Abstract

In the present study liposomal formulations containing Famotidine were prepared and studied. Liposomal formulations were evaluated for drug entrapment, surface characterization and in-vitro drug release studies. Drug excipient compatibility was determined by using spectral studies. Liposomal suspensions were prepared using film hydration technique by varying concentrations of ingredients and optimize the ideal combination for required drug release. The prepared liposomes were rigid, intact and fulfilled all official requirements. The results of in vitro drug release studies showed that release from liposomal formulation was slow and sustained for more than 8 hrs period. Thus the liposomal suspensions of Famotidine were successfully formulated and established for their quality control parameters.

Keywords: Liposome, Drug Release, Formulation, Famotidine