Abstract

FORMULATION, IN-VITRO EVALUATION AND ANALYTICAL QUANTIFICATION OF ZALTOPROFEN MICROCAPSULES

Biresh K Sarkar*, Manish Devgan, Y.Ankamma Chowdary

Abstract

Zaltoprofen was formulated as novel enteric microcapsules for improved delivery using the polymer ethyl cellulose as the retardant material. Micro encapsulation of Zaltoprofen was done to achieve a controlled drug release profile suitable for per oral administration. Microcapsules were prepared by and emulsion solvent evaporation method. The prepared microcapsules were evaluated for different quality control parameter like; size analysis, drug content, encapsulation efficiency, and drug release characteristics etc. Results of study revealed that Zaltoprofen release from microcapsules greatly affected by the size of the microcapsules. A precise UV method also developed for the estimation of zaltoprofen in prepared dosage form. Drug followed the Beer- Lambert’s law in the concentration range of 5- 25μg/ml. Slope, intercept, correlation coefficient, detection and quantization limits were also calculated. Results of the analysis were validated statistically and were found to be satisfactory.

Keywords: Zaltoprofen Micro Encapsulation, Formulation, Evaluation.