Abstract

VARIOUS QUANTITATIVE & QUALITATIVE METHODS FOR ESTIMATION OF ANTI-EPILEPTIC DRUGS IN BULK DRUG, FORMULATIONS AND THEIR BIOLOGICAL SAMPLES –A REVIEW

Sindhu Datla*, Imam Pasha S. and Anupama Koneru

Abstract

This paper describes the various analytical methods reported for quantitative estimation of various drugs used in the treatment of Epilepsy. Quantification of drugs in bulk drug, active pharmaceutical ingredients and their formulation and their impurity profiling is mandatory as per the requirement of governing bodies. Estimation of the drug samples in biological samples is of prime requirement for in Vitro and in vivo studies of bio availability and bio equivalence studies. This paper includes all the analytical methods and bioanalytical methods reported for estimation of various combinations of anti-epileptic drugs in biological and non-biological fluids.

Keywords: Anti-Epileptic drugs; Therapeutic drug monitoring; Estimation; Quantitative.