Abstract

PHYTOCHEMICAL SCREENING AND ANTI-PSORIATIC EVALUATION OF CITRUS SINENSIS PEEL EXTRACTS ON MOUSE TAIL MODEL

B. Vijay Kumar*, G. N. S. S. Chandra Sekhar, Ch. Venkatesh, Y. Manikanta, J. Nagalakshmi and Nadendla Rama Rao

Abstract

Objective: To assess anti-psoriatic activity of the ethanol and aqueous extract from the peels of citrus sinensis on mouse tail model. Methods: Mouse tail test using Perry scientific tail model was used for the evaluation of anti-psoriatic activity. Aqueous extract and ethanol extract of (100mg/kg) were tested in Swiss albino mice. Parameters studied in the mouse tail test were changes in epidermal thickness and percentage orthokeratotic values. Results: The extracts from the peels of citrus sinensis produced significant orthokeratosis (P

Keywords: Citrus sinensis, flucinolone acetonide, orthokeratosis.