Abstract

EFFECT OF JATHIPALATHI CHOORANAM ON CARRAGEENAN INDUCED LOCALISED INFLAMMATORY PAIN IN RATS

A. Janakiram*, A. F. Glara, J. Prabhavathi and Prof. Dr. S. Kaniraja

Abstract

Aim: To study the Anti-inflammatory effect of Jathipalathi Chooranam (JPC) in the Male Wister rats of Carrageenan- induced localized inflammation. Method: The paw edema volumes of the test compounds, standard and control groups were measured at 0, 1, 2, 3, 4, 5, 6th hr after Carrageenan treatment with the help of Digital Plethysmometer. Mean increase in paw edema volume after carrageenan injection was measured and the percentage of inhibition was calculated. Drug and solutions: 1. Carrageenan (0.1ml of 1%) 2. Diclofenac sodium (10mg/kg IP) 3. Jathipalathi Chooranam 1gm per day. Results: The results showed significant (p<0.05) anti inflammatory activity when compared to control group. Conclusion: The test drug JPC shows have an anti-inflammatory activity at the concentration of 3.024mg/kg compared to standard drug, Diclofenac Sodium.

Keywords: Siddha medicine, Jathipalathi Chooranam, Anti-inflammatory activity, Carrageenan induced localized inflammatory pain, Male Wister rats, Pre-clinical study.