Abstract

NIOSOMES A CONTROLLED AND NOVEL DRUG DELIVERY SYSTEM: A BRIEF REVIEW

Mohd Iqbal Bhat*, Ganesh N. S., Tanzeel Majeed and Vineeth Chandy

Abstract

During the past many year's formulation of vesicles is used as a tool to improve the delivery of drugs, it has created a lot of interest among the scientists who are contributing in the particular area of drug delivery system.[1] The vascular system like liposomes, transferosomes, Niosomes, phytosomes and electrosomes provide an effective path to amend the drug delivery. Niosomes play vital role owing to their nonionic properties, in this type of drug delivery system.[2] Conception and evolution of a novel drug delivery system (NDDS) have two requirements. Foremost, the drug should be pitched at a predetermined rate and second, it should release therapeutically effective amount of a drug at the site of activity. The conventional dosage form does not satisfy these demands. Niosomes are non-ionic surfactant based unilamellar or multilamellar vesicles these vesicles possess an aqueous solution in which solute is entirely enveloped by a membrane resulting from organization of surfactant macromolecules. Niosomes are widely considered as an alternative to liposomes.[3] Both the vesicles are used to better the therapeutic performance of the drug molecule by delaying clearance from the circulation, protecting the drug from the biological environment and restricting effects to target cell. The application of niosomal technology is widely practiced to treat a number of diseases.[4]

Keywords: Niosomes, non-ionic surfactant, novel drug delivery system, vesicles.