Abstract

SIGNIFICANT PHARMACOLOGICAL / BIOLOGICAL ACTIVITIES OF NOVEL QUINAZOLINE DERIVATIVES IN MEDICINAL CHEMISTRY

Shirish P. Gavit* and Amol S. Jagdale

Abstract

This review paper highlights biological and pharmacological utility of some quinazoline derivatives. Quinazolinones are large classes of bioactive chemical compounds exhibiting broad spectrum biological activities in animals as well as in humans. Literature studies on quinazolinones have shown that these derivatives possess a wide variety of pharmacological activities such as anti HIV, Anticancer, Antifungal, Antibacterial, Anti-mutagenic, Anti-coccidial, anticonvulsant, anti-inflammatory, CNS depressant, Anti-malarial, Antioxidant, Anti-leukemic activity, anti-leishmanial activity.

Keywords: Quinazoline, Quinazolinones, Bioactive.