Abstract

TAURINE MODULATES NEUROBEHAVIORAL IMPAIRMENTS IN LAMBDA CYHALOTHRIN INDUCED MALE ALBINO RATS

Barun Chakroborty, Ananya Pradhan, Prasanta Maiti and
Dr. Sujata Maiti Choudhury*

Abstract

Taurine, a sulfur-containing α-amino acid, is widely distributed in most mammalian tissue. Lambda cyhalothrin (LCT), is a broad-spectrum type II synthetic pyrethroid that imitate the properties of the natural insecticide pyrethrin from chrysanthemum flowers. The aim of this study was to evaluate the modulatory role of taurine (TAU) on locomotor activity and neurobehavioural alterations in LCT intoxicated male albino rat. Mature 36 Wistar male albino rats were randomly divided into six groups. After pre-treatment of taurine (50 mg/kg body weight), lambda-cyhalothrin was given orally for consecutive 14 days at two dose levels (10.83 and 15.17 mg/kg body weight) alone or in combination. Neuro-behavioural changes or signs of intoxications were measured by behavioural studies including locomotor and nonlocomotor activities (Open-field test) and mouse-killing (muricide) test. Brain serotonin level was evaluated spectrophotometrically from control and treated rat brain tissue. In LCT treated rats, a significant decrease in locomotor activity, emotional behavior and cerebral and cerebellar serotonin level were seen. Exposure to LCT thus elicited significant changes in neurobehavioral activity and emotional behaviour and significant restoration were observed due to pre-administration of taurine. In conclusion, these results indicate that the ability of TAU as a neuromodulator to protect brain against LCT-induced neurobehavioral alterations.

Keywords: Taurine; Lambda cyhalothrin; Neurohavioural activity; Emotional behaviour; Serotonin level.