Abstract

EVALUATION OF ANTI DIARRHEAL ACTIVITIES OF ETHANOLIC EXTRACT OF HIBISCUS PLATANIFOLIUS IN CASTOR OIL INDUCED DIARRHEA IN WISTAR ALBINO RATS

Mortha Madhu Babu*, Dr. I. Sudheer Babu and Y. Jyothi Krishna

Abstract

The plant Hibiscus platanifolius belongs to the family Malvaceae, which is being used traditionally for various disorders of hypertension, kidney and used as natural diuretic. Hibiscus -platanifolius has been proposed to contain anti diarrheal properties such as flavonoids, anti – oxidants, tannins, terpenes, alkaloids. This study was designed to evaluate anti diarrheal activity by castor oil induced diarrhea and castor oil induced enteropooling in rats, for two methods have selected four groups individually in which group 3 & 4 received plant extract (200mg/kg, 400mg/kg) and first group received normal saline (5ml/kg) as disease control and second group received loperamide (5mg/kg) and one hour before the test and standard all the animals received castor oil (2ml/ rat) in both methods. In castor oil induced method rats were kept in transparent metabolic cages and collected diarrheal and non diarrheal feces for 6 hours and assessed activity where as in castor oil induced enteropooling method rats were sacrificed and collected intestinal contents by milking into graduate tube and their volume measured.

Keywords: Diarrhea, Hibiscus platanifolius, Castor oil, Diarrhea, loperamide.