Abstract

A CASE REPORT ON PREDNISOLONE INDUCED HYPERGLYCEMIA IN CHRONIC KIDNEY DISEASE AND ROLE OF CLINICAL PHARMACIST

Saikiran Velpula*, Nagaraju Vallepu, Bharathkumar Dasari, Laxmi prasanna Gummadi, Mahalaxmi Pykarao, Shyam Sunder Anchuri, Manishkumar Thimmaraju

Abstract

Prednisolone is a 1, 2-dehydrocortisol which is highly potent syntheticglucocorticosteroid which has minimal mineralocorticoid activity. Likeimmunosuppressive or anti inflammatory agent Prednisolone can alsobe used, which indicated in the treatment of various conditions,including congenital adrenal hyperplasia, psoriatic arthritis, systemiclupus erythematous, bullous dermatitis herpetiformis, seasonal orperennial allergic rhinitis. Majorly it causes Cushing Syndrome, pepticulceration, edema, hypokalemia, muscle weakness, behavioralchanges. Hyperglycemia is the most common side effect ofGlucocorticoids and more representative. A 60 year old male patientwas consulted in the nephrology department with chief complaints ofshortness of breath, past medical history of patient includes hyperntension, diabetis mellitus,chronic kidney disease, In-order to prevent serious adverse drug reactions of this drug, closemonitoring during treatment course, creating awareness, recognition of the problem andcareful management of all patients who receive this medication are essential.

Keywords: Prednisolone, hyperglycemia, adverse drug reaction.