Abstract

FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLETS OF URAPIDIL

K. Kalyani* M. Meera Devi, B. Sunitha and Sukanya

Abstract

The aim of present study was to develop the Urapidil oral disintegrating tablets thereby enhancing the solubility and dissolution rate. Dissolution rate was enhanced by using various disintegrants like Ocimum mucilage, Locust bean gum, Sodium Starch Glycolate, β- cyclodextrin, poloxamer 407 and it was further confirmed by phase solubility studies. The formulated tablets were evaluated and the parameters such as weight variation, hardness, friability, drug content, thickness, disintegration and dissolution studies were compiled with the official limits. From the in-vitro dissolution studies, it was observed that the formulation F6 consists of Locust bean gum showed maximum drug release (99.96%) in 25 minutes. FTIR data also reveals that there is no chemical interaction between drug and excipients in the present investigation.

Keywords: Urapidil, oral disintegrating tablets, locust bean gum, dissolution rate.