Abstract

EVALUATION OF SERUM LIPID PROFILE IN PATIENTS WITH ORAL POTENTIALLY MALIGNANT DISORDERS AND ORAL SQUAMOUS CELL CARCINOMA -A CASE CONTROL STUDY

Dr. Srividhya Srinivasan* Mds and Dr. Anand B. Mds

Abstract

Lipids are the major cell membrane components, which are essential for various biological functions, such as maintaining cell integrity, cell growth, and division of normal and malignant cells. Hypocholesterolemia has been observed in patients with cancers of various organs; however the potential role of alterations in serum lipid profile in oral cancer remains controversial. It has been suggested a causative relationship might exist between plasma lipid levels and oral cancer patients. Further, the habit of tobacco consumption is on the rise and most often the oral cancer patients are afflicted with this menace. This study is conducted to understand the role of these lipids in the oral potentially malignant disorders like Oral Leukoplakia, Oral Submucous fibrosis and also in Oral Squamous Cell Carcinoma. A total number of 75 patients were involved in the study An inverse relationship exists between serum lipid profile in Oral cancer and Oral Potentially Malignant disorders. The lower serum lipid status may be a useful indicator for initial changes occurring in neoplastic cells

Keywords: Lipid, Oral Cancer, Oral Potentially Malignant Disorders.