Abstract

VASCULAR ENDOTHELIAL GROWTH FACTOR, DIABETES MELLITUS AND PERIODONTAL DISEASE INTERRELATIONSHIPS - A REVIEW

Dr. Ramya V.*, Dr. J. Bhuvaneswarri, Dr. Vidhyarekha, Dr. Preethepaddmanabhan

Abstract

Vascular endothelial growth factor a 46 KD homodimeric glycoprotein is an endothelial – specific growth factor. Periodontitis is an infection of highly vascularised supporting tissues. Diabetes mellitus is often related to increased gingival inflammation as a response to plaque accumulation. There are many reports investigating the relationship between periodontitis and diabetes mellitus and Numerous cytokines and growth factors are involved in the regulation of angiogenesis, including members of Transforming growth factor α, and Transforming growth factor ß, Hepatocyte growth factor, Tumor necrosis factor, Interleukin 8. Of all, the most potent agent that acts specifically on vascular endothelium is vascular endothelial growth factor (VEGF). This article reviews the importance and the involvement of VEGF in periodontal disease and diabetes mellitus.

Keywords: Vascular Endothelial Growth Factor, Angiogenesis, Periodontitis.