Abstract

COLON ULCER INDUCED BY ALENDRONATE AND CURE IT WITH METHYL SULFONYL METHANE

Safaa William Mdawar, Shaza Anwar Al Laham* and Ahmad Izzat Al-Manadili

Abstract

Background: Bisphosphonates define a class of drugs which are widely indicated to treat osteoporosis both in men and women. Side effects of the oral tablets may include nausea, difficulty swallowing, heartburn, irritation of the esophagus and gastric ulcer. Methylsulfonylmethane (MSM), which has become a popular dietary supplement, was used to treat Bisphosphonates ulceration. Our objective was studying the effect of MSM on treat colon ulcer induced by Alendronate (ALN) in rats using different doses of MSM. The experiments had been done on 8 white wistar rats for each group. The colon ulcer had been induced by administration of Alendronate (20mg/kg/day) by gavage for 4 days. MSM (400mg/kg/day) has been given, for the first therapeutic group, for 4 days after administration of Alendronate, while the other therapeutic group has been given MSM (800 mg/kg/day). The ulcers in rats' colon were examined histologically and microscopically. Results indicated the inability of MSM to treat the colonic ulceration induced by Alendronate in both doses 400 and 800 mg/kg/day for four days. Conclusion: MSM both doses (400 mg/kg/day) and (800 mg/kg/day) have no therapeutic effect of colon ulcer induced by alendronate.

Keywords: Gastrointestinal. Colon ulcer. therapeutic. Alendronate. Methyl sulfonyl methane.