Abstract

DEVELOPMENT OF NABUMETONE TOPICAL GELS: EFFECT OF FORMULATION VARIABLES ON THE RELEASE OF NABUMETONE

Ganesh Shingade*

Abstract

Topical gels of Nabumetone were prepared using two different gelling agents (viz, carbopol and hydroxypropylmethylcellulose). Formulations were evaluated for pH,drug content and in vitro drug diffusion. Formulations of both the gelling agents appeared to be non‐Newtonian and pseudo plastic. Drug content was found to be high (>90%) and uniform in gels. Effect of solvents, propylene glycol and ethanol on the release of drug from the gels was studied. Drug release from the gels increased with increase in the concentration of propylene glycol up to 10%. However, drug release decreased with further increase in the concentration of the Propylene glycol to 20%. In case of carbopol gels, drug release increased with the addition of ethanol. However, in case of hydroxypropylmethylcellulose gels, addition of ethanol decreased the release of Nabumetone. The release of NAB from the gels followed the Higuchi model. It can be concluded that propylene glycol acts as a good solvent in carbopol and hydroxypropylmethylcellulose based Nabumetone gels.

Keywords: Nabumetone; topical gel; In vitro release.