Abstract

PHARMACOSOMES: A NOVEL CARRIER FOR TARGETED AND CONTROLLED VESICULAR DRUG DELIVERY SYSTEM

Vijay Kumar Singh*, Anand Patel, Dinesh Chandra, Kamlesh.K.Yadav

Abstract

Vesicular drug delivery system showed application in targeted and controlled drug delivery and transport the active agent to the tissue through biological barriers. Novel vesicular drug delivery carrier intend to delivery the drug at a rate directed by the need of body during the period of treatment and channel the active moity to the site of action providing target. Pharmacosomes are one of the most promising approaches for this system to increase the bioavailability of drug substance, improve drug stability, and prolong the existence of the drug in systemic circulation and target drugs to specific site in the body. Pharmacosomes are amphiphilic, colloidal dispersion prepared from drug lipid conjugates with or without additional surfactant. Targeted pharmacosomal drug delivery system is very useful in caner therapy because such pharmacosomes should selectively localize anticancer drug at the tumour site, thus reducing the toxicity of the drug to normal cell and improving their therapeutic activity. The great advantages of pharmacosomes are it may be minimize drug degradation and diminised the toxicity (GIT).

Keywords: Vesicular system, Concept of targeting, Carrier, Pharmacosomes.