Abstract

A REVIEW ON SOLID DISPERSION AND ITS APPLICATION

G. Y. Srawan Kumar*, G. Naveen, J. Anand Babu, K. Gopi Krishna, K. Gopi. D. Rama Brahma Reddy

Abstract

The drugs have been classified into 4 categories by BCS classification system. Based upon permeability and solubility parameters. In formulation most of the drugs are poor solubility, due to this the bioavailability of the drug In vivo conditions is less. To improve the bioavailability of this type of drugs, the solubility is enhanced by various approaches in this research work we approach solid dispersion technology for improving the solubility of poorly soluble drugs and adopted by various preparation methods. This formulation is used in various drug delivery systems i.e. oral, tropical, parental, ocular, etc.....These formulations can be used to verity of drugs such as amorphous and crystalline substances. Recently, solid scale systems have received much interest as a way to resolve solubility issues because of their cost-effectiveness and technical simplicity compared to liposome’s and other colloidal drug carriers. Solid dispersion have proven to be a better alternative over other approaches currently available for improving bioavailability of number of drugs with low solubility. Solid dispersion have been extensively developed for a wide range of drugs and have been evaluated for in vitroand in vivo applications by various routes. They have alsobeen used for drug targeting. In fact, the number of products based onsolid dispersion in the market and under clinical study is higher than that of othertechnology-based applications. A surprisingly large proportion of new drug candidatesemerging from drug discovery programs are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. Solid dispersion is an effective way of improving the dissolution rate of poorly water soluble drug and hence it's bio availability. The water soluble carrier used in preparation is solid dispersion enhance the dissolution rate of the poorly water soluble drug. The review article focus on the methods of preparation, advantage, dis-advantages,& characterization of the solid dispersion.

Keywords: Solid dispersion, type of solid dispersion, carrier, polymer, drug release, drug polymer interaction.