Abstract

FORMULATION AND INVITRO EVALUATION OF FLOATING S.R TABLETS OF NORFLOXACIN

K.L. Deepthi*, V. Mercy Pourna Chandra, K. Rushali Reddy, S. Harsha Sree

Abstract

The main aim of present study is gastroretentive delivery systems of Norfloxacin was successfully developed in the form of hydro dynamically balanced tablets to improve the local action and its bioavailability, which reduces the wastage of drug and ultimately improves the solubility for drugs that are less soluble in high pH environment. Norfloxacin can be developed to increase gastric residence time and thereby increasing its bioavailability. Norfloxacin floating tablets were prepared by using HPMCK4M, HPMC K15M, Carbopol 934P polymers with excipients-sodium bicarbonate and lactose. The prepared formulation can be used to perform in-vivo studies in animals. The floating tablets were evaluated by various physicochemical parameters like hardness, friability, thickness, weight variation and content uniformity.

Keywords: Norfloxacin, Hydro dynamically balanced systems, swellingindex, HPMC, Carbopol 934P.