Abstract

ASSOCIATION OF AGE AND GENDER WITH DEVELOPMENT OF LIVER CIRRHOSIS AMONG HEPATITIS B VIRUS INFECTED INDIVIDUALS IN SUDAN

Mudathir Abdelshafea Abdelkareem Abakar*, Kafi S. K., Eltayib Hassan Ahmad-
Abakur and Musa Mohammad Ahmed Hammad

Abstract

The progress of liver cirrhosis among HBV patients can be affected by the viral load, immunity of the patient and environmental factors. This study aimed to associate age and gender as factor for development of liver cirrhosis in HBV patients. Information of gender, age and liver cirrhosis were collected from ninety HBV patients in different clinical status through instructed interview questionnaire, and sera from the participants were collected and tested for HBV viral load and liver enzymes alanine transaminase (ALT) and aspartate transaminase (AST). Liver cirrhosis was significantly associated with male gender (P= 0.034), older age (P= 0.000) and aging in both of males (P=0.007) and females (P=0.001). HBV infection and liver cirrhosis are significantly most frequent in males than females with significant increase among females older than 45 years old. The serum levels of HBV viral load was elevated among male and female with older age and liver cirrhosis. AST and ALT are elevated in males and younger age group.

Keywords: Age, Gender, HBV, Liver cirrhosis.