Abstract

ASSESSMENT OF AST AND ALT AMONG DIFFERENT CLINICAL CATEGORIES OF HBV INFECTED INDIVIDUALS AT KHARTOUM STATE-SUDAN

Mudathir Abdelshafea Abdelkareem Abakar*, Kafi S. K., Eltayib Hassan Ahmad-Abakur and Musa Mohammed Ahmed Hammad

Abstract

Alanine transaminase (ALT) and aspartate transaminase (AST) are commonly tested to reflect the general liver health status because they increased in liver diseases. This study aimed to assess the levels of AST and ALT among different categories of HBV patients. A ninety sera were collected from HBV patients, 30(33.3%) of the participants were suffering from liver cirrhosis, 30 (33.3%) carriers, 19 (21.2%) acute HBV patients and 11 (12.2%) recently infected. 8(26.7%) of the carriers were positive for HBeAg as active chronic carriers. The serum levels of AST and ALT were measured by full automated chemistry analyzer. There were significant mean differences of AST and ALT among different study groups (P values 0.000 and 0.003 respectively). Both enzymes were elevated in recent HBV infected group then acute hepatitis, HBV with liver cirrhosis and HBV carriers. AST elevation was predominant among cirrhosis and elevated ALT does not accurately predict significant liver injury.

Keywords: AST, ALT, HBV, Live cirrhosis.