Abstract

ENHANCEMENT OF AQUEOUS SOLUTION AND BIOAVAILABILITY OF POORLY WATER SOLUBLE DRUGS BY SELF EMULSIFYING DRUG DELIVERY SYSTEM

Aravindh Govindharasu*, Elango K. and Deattu N.

Abstract

The Self emulsifying Drug Delivery System (SEDDS) is a Novel Drug Delivery System for Enhancement of water solubility of poorly water soluble drugs. It is isotropic mixture of oil, surfactant, co-surfactant molecules and it also containing co-solvent molecule. It is Drug delivery system is thermodynamically and kinetically stable. The drug delivery system under mild agitation is followed by dilution of aqueous media such as GI fluid and it can from stable O/W emulsion. It is important type of Drug delivery system to maintain the chemical stability as well as solubility of drug product. The Self emulsifying Drug Delivery System (SEDDS) is important application on BCS Class II and Class IV Drugs for improving water Solubility of poorly water soluble drugs. It is important to prevent the interfacial tension and improving the dissolution as well as absorption rate of drug molecule. It is Novel Drug Delivery System is Applicable for parenteral, Ophthalmic, intranasal and cosmetic drug delivery system.

Keywords: Nanoemulsion, Microemulsion, Surfactant, Self-emulsifying system, Improving water solubility, Bioavailabillity enhancement.