Abstract

MATRIX TABLET: AS A SUSTAINED RELEASE DRUG DELIVERY SYSTEM

Anil B. Phad*, N. B. Mahale, Dr. S. R. Chaudhari, Dr. K. S. Salunke

Abstract

Now a day‟s pharmaceutical industry focusing for development of sustained release oral dosage forms as it become an important tool in medical practice. These sustained release formulations are designed to release drug in pre-determined rate and able to maintained plasma drug concentration in therapeutic window with minimum side effects. The basic rational behind sustained release drug delivery is to alter biopharmaceutical, pharmacokinetic and pharmcodynamic of drug to reduce side effect, give patient compliance and cure the disease. Sustained release drug delivery is improved patient compliance due to less frequent drug administration, reduction of fluctuation in steadystate drug levels, maximum utilization of the drug, increased safety margin of potent drug, reduction in healthcare costs through improved therapy and shorter treatment period. The principal goal of sustained release forms is the improvement of drug therapy assessed by the relationship between advantages and disadvantages of the use of sustained release system. This review article contained basic information of matrix type of sustained release drug delivery system.

Keywords: sustained release, Matrix tablet, oral drug delivery system.