Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MICROSPHERES OF LOSARTAN POTASSIUM BY SPRAY DRYING TECHNIQUE

Kanawade Sunil S*, SalunkheKishor S, Chaudhari Sanjay R

Abstract

Losartan Potassium is antihypertensive agent called angiotensin II receptor blockers (ARBs).is a highly water soluble drug. Losartan Potassium has shorter half-life of 2.1± 0.70 Hrs and after oral conventional administration mostly it is degraded in the liver and does not show prolonged effect.To overcome these problems the sustained release microspheres of Losartan Potassium is developed which will deliver the drug over a longer period of time. Microspheres of Losartan Potassium were prepared by spray drying technique using the lipophillic polymers i.e.EudragitRS100 and Ethyl Cellulose in drug:polymer ratio 1:8.The microsphere of Losartan Potassium showed an increasing trend of entrapment efficiency and in-vitro drug release. The in vitro drug release study suggests the sustained release of drug despite being highly water soluble.Scanning electron microscopy, differential scanning calorimetry and FT-IR study of the drug and formulation was carried out.

Keywords: antihypertensive, microspheres, spray drying, Losartan Potassium.