Abstract

FABRICATION AND CHARACTERIZATION OF ITRACONAZOLE LOADED NANOSPONGE GEL

*Nagasubba Reddy N., Stella Parusha, Ayyanna, Lavanya, Uday Kumar, Priyanka

Abstract

The present study was carried out to utilize and to easily done by using polymeric ‘Nanosponges’ as an alternative carrier for targeting and controlled Itraconazole to the skin through topical gel formulation. Itraconazole is a second generation azole antifungal agent. Nanosponges are porous polymeric drug delivery system and they were helped to reduce irritation without reducing efficacy and it can be effectively incorporated into topical gel formulation. These Nanosponges are prepared by using emulsion solvent diffusion method and they were formulated by using polyvinyl alcohol and ethyl cellulose, dichloromethane. The selected Nanosponges are formed into gel by adding carbopol 934 using varying concentrations of permeation enhancers (propylene glycol) and pH neutralizer (triethanolamine) and itraconazole Nanosponges loaded gels (F1-F10) were evaluated by using SEM analysis, particle size determination and dissolution studies, drug entrapment efficiency etc.

Keywords: Itraconazole, Topical gel, Nanosponges.