DESIGN AND CHARACTERIZATION OF BUCCAL PATCHES OF CANDESARTAN CILEXETIL
Yella Thirupathi Reddy*, Rohit Saraswat and Reddy Sunil
Abstract
Buccal route provides one of the potential routes for typically large,
hydrophilic and unstable proteins, oligo nucleotides and
polysaccharides as well as conventional small drug molecules. The oral
cavity can be used for local and systemic therapy. Bucca patches of
Candesartan Cilexetil was prepared by using polymers HPMC E-15,
Sodium Alginate, Chitosan, Pectin, Eudragit RL-100, by employing
solvent casting method. DCM: Methanol volume ratio, Glycerin &
Propylene Glycol were selected as permeation enhancer and
plasticizer. all the formulations prepare (F1-F16) were evaluated for
various physical parameters Physical appearance, Flatness, Weight
variation, Thickness, Folding endurance, Drug content, Moisture
uptake, Moisture content and Swelling study and all the results were found to be were found
to be within the pharmacopeial limits, in-vitro drug release studies by using dialysis
membrane. Among all the 16 formulations F4, F7, F11 and F16 formulation which contain
HPMC E-15, Sodium Alginate, Chitosan, Pectin, Eudragit RL-100 had shown F4 formulation
91.96 ± 0.029, F7 formulation 87.94 ± 0.060, F11 formulation 82.45 ± 0.027 and F16
formulation 93.15 ± 0.038. Cumulative drug release within 6 hours. Drug excipient
compatibility studies were carried out by using FTIR, DSC and it was observed that there
were no interactions.
Keywords: Cumulative Drug Release, Buccal Patches, Candesartan Cilexetil.
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