Abstract

INACTIVATION OF USP (RV2623) PROTEIN OF MYCOBACTERIUM TUBERCULOSIS H37RV USING STRUCTURE –BASED DRUG DESIGN APPROACH

Zahra M. Al-Khafaji*, Marium B. Mahmood and Aaisha B. Mahmood

Abstract

Tuberculosis is a serious threat worldwide. Mycobacterium tuberculosis, the causative agent is very successful intracellular pathogen due to having various facilities for survival. Dormancy/latency is one of these abilities as it constrains the eradication of the disease. The case facilitated by universal stress proteins (USPs) which are induced upon exposure to stresses. This study aimed to look for inhibitors for the most important USP protein RV2623, using computational structure-based drug design approach. Four inhibitors were obtained directly or after modifications, those were docked strongly with chain F and chain H of the protein (pdb ID 3cis).

Keywords: Tuberculosis, Mycobacterium tuberculosis H37Rv, universal stress proteins, Drug design, latency.