FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET BY USING SUBLIMATION TECHNIQUE
*Kalpesh Alai, V.M. Thakare, B.W. Tekade, and V.R. Patil
Abstract
Telmisartan is a drug of the angiotensin II receptor antagonist used in
the management of hypertension. The present investigation was to
develop and characterize mouth dissolving tablets of telmisartan using
sublimation technique. Mouth dissolving tablets of Telmisartan were
prepared using different subliming agents like camphor different
concentrations of using sublimation method. The technique is to
increase the porosity of the tablets whereby subliming material was
sublimed from the granules by exposing the granules to vacuum. The
porous granules were then compressed in to tablets. Alternatively,
tablets were first prepared and later exposed to vacuum. The drug and
excipients were characterized using DSC and FTIR techniques. The
blend was examined for angle of repose, bulk density, tapped density,
compressibility index and Hausner’s ratio. The prepared tablets were
evaluated for general appearance, content uniformity, hardness,
friability, taste evaluation, mouth feel, wetting time, in vitro and in vivo disintegration time,
and in vitro dissolution studies. The optimum formulation was chosen and their optimum
results were found to be in close agreement with experimental finding. Among all F1 to F10
formulation and F8 emerged as overall best formulation. Optimized tablets have shown no
appreciable changes with respect to taste, disintegration, and dissolution profiles. In
conclusion, sublimation is a useful technique to enhance the solubility and dissolution rate of
poorly water-soluble drug like telmisartan.
Keywords: Mouth dissolving tablet, sublimation technique, telmisartan, subliming agent, superdisintegrants.
[Full Text Article]